The 450’th episode of WWE SmackDown came to you from the Crown Coliseum in Fayetteville, NC.
- 4-Man Over The Top Rope Challenge: Mark Henry def. Chuck Palumbo, Kane, & The Great Khali (Kane eliminates Chuck Palumbo, Mark Henry eliminates Kane, & Mark Henry eliminates The Great Khali)
- CM Punk (ECW) def. John Morrison (ECW) by pin following the GTS.
- 6-Man Tag: Kofi Kingston (ECW), Jesse (SmackDown), & Festus (SmackDown) def. The Miz (ECW), Lance Cade (RAW), & Trevor Murdoch (RAW) by Kofi Kingston pinning The Miz following the Jamaican Buzzsaw.
- Batista (SmackDown) def. Snitsky (RAW) by pin following the Batista Bomb.
- WrestleMania Wet N’ Wild Water Fight: Special Referee- Eve Torres: Michelle McCool & Cherry def. Victoria & Maryse by Michelle McCool pinning Victoria following the Wings of Love.
- Champion Vs. Champion: Non-Title: Chris Jericho (RAW) def. MVP (SmackDown) by DQ when MVP attempts to hit Chris Jericho with the United States Title belt.
- CM Punk Vs. John Morrison
- MVP Vs. Chris Jericho
- Over The Top Rope Challenge
- 6-Man Tag
- Wet N’ Wild Water Fight
- Snitsky Vs. Batista
It was announced (scrolling on the bottom of the screen) that the Big Show Vs. Floyd "Money" Mayweather match at WrestleMania XXIV will be an Anything Goes Match, where the match can be won by Pinfall, Submission, or Knock-Out.
Eve Torres was eliminated from the Best SmackDown Diva Contest; Cherry & Michelle McCool remain.