The 466’th edition of WWE SmackDown came to you from the Time Warner Cable Arena in Charlotte, NC.
- Special Guest Referee- Edge: Hawkins & Ryder (SD) def. Finlay & Hornswoggle (ECW) by Zack Ryder pinning Finlay following the Spear by Edge.
- 4-on-1 Handicap Match: Big Show and The Great Khali, MVP, Shelton Benjamin*, & Vladimir Kozlov fight to a No Contest when all competitors enter the ring.
- Natalya def. Cherry by submission to the Sharpshooter.
- Vickie def. Cherry by pin while Cherry was still down from the Sharpshooter.
- Brian Kendrick (with new bodyguard Ezekiel) def. Jimmy Wang Yang (in his return from suspension) by pin following Sliced Bread #2.
- Umaga def. Mr. Kennedy by pin following the Samoan Spike.
- Non-Title: The Miz & John Morrison (ECW) def. Jesse & Festus (SD) by The Miz pinning Jesse following the Reality Check.
- Brother Vs. Brother: Non-Title: Matt Hardy (ECW) & Jeff Hardy (SD) fight to a No Contest when The Family interferes.
- Matt Hardy Vs. Jeff Hardy
- Brian Kendrick Vs. Jimmy Wang Yang
- 4-on-1 Handicap Match
- Jesse & Festus Vs. The Miz & John Morrison
- Hawkins & Ryder Vs. Finlay & Hornswoggle
- Umaga Vs. Mr. Kennedy
- Natalya Vs. Cherry
- Vickie Vs. Cherry
The Wedding of Edge & Vickie Guerrero took place on SmackDown in a pre-taped segment and the show was dedicated to the Wedding Reception.
*It was announced during the Handicap Match that Shelton Benjamin will challenge Matt Hardy for the United States Title at this Sunday’s Great American Bash.